TYRPHOSTIN AG490 型号:BS32-T3434

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Tyrphostin AG 490 solid Synonym： 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide Molecular Formula：C17H14N2O3 Molecular Weight：294.30 CAS Number：133550-30-8 Descriptions Biochem/physiol Actions： Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma. Caution： Photosensitive References： Abe, et al., Fyn and JAK2 mediate Ras activation by reactive oxygen species. J. Biol. Chem. 274, 21003-21010, (1999) abstract Al-Shami, et al., Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase. J. Biol. Chem. 274, 5333, (1999) abstract Potier, et al., Protein tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices. Brain Res. 816, 587-597, (1999) abstract Eriksen, K.W., et al., Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia 15, 787-793, (2001) abstract

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